THE SINGLE BEST STRATEGY TO USE FOR PKRRATING

) mechanism16,30–34 [to get a contrary look at see35]. The BTB dimer orients the Energetic internet sites clear of the dimer interface in a configuration that cannot mediate this reaction. below, we report structures of wild-sort, unphosphorylated PKR kinase. The kinase domains interact via the BTB interface and undertake an active conformation i